Moderate intensity continuous and high intensity interval training as strategy cardioprotective on cardiotoxicity induced by cancer. Randomized clinical trial

Abstract Introduction The adverse physiological consequences of cancer therapy have been recognized for some years. However, Cardio-Oncology aims to detect and manage cardiac dysfunction induced by treatment (Cardiotoxicity) one the strategies used is physical exercise, which has shown benefits in cardiovascular fitness patients with cancer; therefore, this clinical trial like objective determine effects Moderate Intensity Continuous Training (MICT) High Interval (HIIT) on cardiotoxicity antitumoral treatment. Methodology Randomized controlled 3 years 4 months a sample 753 stage II (Prostate cancer, breast, colorectal, thyroid, cervico-uterine, lung, stomach, liver) distributed groups (MICT, HIIT control group). Echocardiogram, biomarkers, stress test, hemodynamic parameters, risk factors, hematological samples blood glucose lipid profile were identified. In addition, 6-minute walk, anthropometry, quality life, fatigue, sarcopenia, depression, anxiety. tests performed before after 36 session 70-minute training, times per week. A database was created results questionnaires pre post training. Then, descriptive statistics carried out estimate, normality data assessed Kolmogorov-Smirnov test indication specificity evident all analyzes. Also, through Tukey ANOVA analysis variance (two-way variance) used, subsequently, hoc assess characteristics different age groups, gender anthropometry. cases, significance level 5% (p= <0.05). Results After exercise program, there an increase ejection fraction (EG1: 37±3 vs 41±3; EG2: 39±4 47±5; CG: 40±3 40±1; p<0.05). fact, higher values observed Vo2p experimental group 2-HIIT (7.7±6.4 9.8±3.9) compared 1-MICT (8.0±4 8.5±3) (9.0±5.6 9.2±3.9). Likewise, systolic pressure (139±11 129±2), diastolic (86±6 80±1), maximum heart rate (168±11 179±8) life (109±12 76.5±10). It possible show significant changes variables MICT <0.05) group. Conclusions improved ventricular fraction, tolerance, anxiety, strength, vo2p, MHR, fatigue associated others lipidic life. it demonstrate greater It's noteworthy that without decreased vo2 muscular force increased depression Funding Acknowledgement Type funding sources: Private company. Main source(s): Centro de Estudios e Investigaciόn FISICOL